Focal segmental glomerular sclerosis: The cellular lesion
نویسندگان
چکیده
منابع مشابه
Recurrence of focal segmental glomerular sclerosis (FSGS) after renal transplantation.
Focal segmental glomerular sclerosis (FSGS) is a pathological term to indicate glomerular lesions associated with distinctive clinical features. In most cases, FSGS is primary in nature and is called idiopathic. Idiopathic FSGS is often associated with a nephrotic syndrome (NS) and may affect both children and adults. While the prognosis of FSGS is relatively good for patients with subnephrotic...
متن کاملFocal segmental glomerulosclerosis: prognostic implications of the cellular lesion.
The cellular lesion (CELL), seen in some patients with primary focal segmental glomerulosclerosis (FSGS), comprises proliferation, hypertrophy, and pathologic changes in the cells overlying the glomerular scar. The prognosis of the cellular lesion was retrospectively studied in 100 patients with FSGS (43 had FSGS-CELL and 57 had FSGS without the cellular lesion (classic segmental scar [CS]). Pa...
متن کاملGlomerular Endothelial Cell Injury and Focal Segmental Glomerulosclerosis Lesion in Idiopathic Membranous Nephropathy
BACKGROUND Focal segmental glomerulosclerosis (FSGS) lesions have often been discussed as a negative predictor in idopathic membranous nephropathy (MN). The mechanism of the development of FSGS lesion in MN is still uncertain. METHODS From 250 cases of MN, 26 cases contained FSGS lesion. We compared the clinicopathological characteristics between MN cases with FSGS lesion [MN-FSGS(+)] and MN ...
متن کاملFocal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in no...
متن کاملFocal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis.
We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved u...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1985
ISSN: 0085-2538
DOI: 10.1038/ki.1985.225